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2,3-dinor Prostaglandin E1

Cayman Chemical Item Number 13120

2,3-dinor PGE1 (CAS 7046-40-4)

2,3-dinor Prostaglandin E1 (CAS 7046-40-4)

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Description

Prostaglandin E1 (PGE1) is not a major naturally occurring prostaglandin, but it is widely administered clinically for several indications including peripheral occlusive vascular disease, erectile dysfunction and in neonatal cardiology.1,2 The metabolism of PGE1 is normally initiated by oxidation at C-15, resulting in 13,14-dihydro-15-keto PGE1 as the major metabolite. However, inhibition of this pathway or saturation by excess substrate could theoretically lead to enhanced production of 2,3-dinor metabolites, including 2,3-dinor PGE1. The biological activity of 2,3-dinor PGE1 has not been published. Cayman Chemical is a leading supplier of prostaglandins and their metabolites, and is currently the exclusive manufacturer of 2,3-dinor PGE1.

1 Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

2 Hoshi, K. Approved indications of lipo-PGE1 in Japan. Adv Drug Deliv Rev 20 171-176 (1996).

Synonyms
  • 2,3-dinor PGE1
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​2,​3-​dinor-​prost-​13E-​en-​1-​oic acid
CAS Number 7046-40-4
Molecular Formula C18H30O5
Formula Weight 326.4
Formulation A solution in ethanol
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C1[C@H]​(CCCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1

Background Reading

Virag, R., Shoukry, K., Floresco, J., et al. Intracavernous self-injection of vasoactive drugs in the treatment of impotence: 8-Year experience with 615 cases. J Urol 145 287-293 (1991).

Hoshi, K. Approved indications of lipo-PGE1 in Japan. Adv Drug Deliv Rev 20 171-176 (1996).

2,3-dinor Prostaglandin E1 is available in the following screening library:

Size Price Quantity Subtotal
25 µg $43.00 $0.00
50 µg $82.00 $0.00
100 µg $155.00 $0.00
1 mg $1,204.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

Prostaglandin E1
Prostaglandin E1 Analytical Reference Standard

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