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Sodium ButyrateCayman Chemical Item Number 13121 Butyric Acid (sodium salt) (CAS 156-54-7) 
Sodium Butyrate (CAS 156-54-7)
Description
Sodium butyrate is a short chain fatty acid that has effects at the molecular, cellular, and tissue level. It has long been known as an inhibitor of histone deacetylases (HDACs).1,2 In cells, this alters the expression of a select group of genes containing butyrate response elements and may also involve Sp1/Sp3 binding sites.3 Sodium butyrate also induces growth arrest, differentiation and apoptosis in cancer cells, primarily through its effects on HDAC activity.4 In addition, it suppresses inflammation, in part by reducing the expression of pro-
1 Boffa, L.C., Vidali, G., Mann, R.S., et al. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J Biol Chem 253(10) 3364-3366 (1978). 2 Sealy, L., and Chalkley, R. The effect of sodium butyrate on histone modification. Cell 14 115-121 (1978). 3 Davie, J.R. Inhibition of histone deacetylase activity by butyrate. J Nutr 133 2485-2493 (2003). 4 Monneret, C. Inhibition of histone deacetylase activity by butyrate. Eur J Med Chem 40 1-13 (2005).
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Joseph, J., Mudduluru, G., Antony, S., et al. Expression profiling of sodium butyrate (NaB)-
Background ReadingMonneret, C. Inhibition of histone deacetylase activity by butyrate. Eur J Med Chem 40 1-13 (2005). Davie, J.R. Inhibition of histone deacetylase activity by butyrate. J Nutr 133 2485-2493 (2003). Sealy, L., and Chalkley, R. The effect of sodium butyrate on histone modification. Cell 14 115-121 (1978). Joseph, J., Mudduluru, G., Antony, S., et al. Expression profiling of sodium butyrate (NaB)- Boffa, L.C., Vidali, G., Mann, R.S., et al. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J Biol Chem 253(10) 3364-3366 (1978). Show all 5 Hide all but first 3Sodium Butyrate is available in the following screening libraries: |
This product is available in custom sizes and/or larger quantities. Please contact our Sales Department for a quote or to purchase. Pricing updated 2012-05-26. Prices are subject to change without notice. To ask for assistance with one of our products please contact a Technical Support Scientist. Warning This product is not for human or veterinary use. Related Products
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins. |
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Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA
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