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Sodium ButyrateCayman Chemical Item Number 13121 Butyric Acid (sodium salt) (CAS 156-54-7) 
Sodium Butyrate (CAS 156-54-7)
Description
Sodium butyrate is a short chain fatty acid that has effects at the molecular, cellular, and tissue level. It has long been known as an inhibitor of histone deacetylases (HDACs).1,2 In cells, this alters the expression of a select group of genes containing butyrate response elements and may also involve Sp1/Sp3 binding sites.3 Sodium butyrate also induces growth arrest, differentiation and apoptosis in cancer cells, primarily through its effects on HDAC activity.4 In addition, it suppresses inflammation, in part by reducing the expression of pro-
1 Boffa, L.C., Vidali, G., Mann, R.S., et al. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J Biol Chem 253(10) 3364-3366 (1978). 2 Sealy, L., and Chalkley, R. The effect of sodium butyrate on histone modification. Cell 14 115-121 (1978). 3 Davie, J.R. Inhibition of histone deacetylase activity by butyrate. J Nutr 133 2485-2493 (2003). 4 Monneret, C. Inhibition of histone deacetylase activity by butyrate. Eur J Med Chem 40 1-13 (2005).
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Joseph, J., Mudduluru, G., Antony, S., et al. Expression profiling of sodium butyrate (NaB)-
Background ReadingMonneret, C. Inhibition of histone deacetylase activity by butyrate. Eur J Med Chem 40 1-13 (2005). Davie, J.R. Inhibition of histone deacetylase activity by butyrate. J Nutr 133 2485-2493 (2003). Sealy, L., and Chalkley, R. The effect of sodium butyrate on histone modification. Cell 14 115-121 (1978). Boffa, L.C., Vidali, G., Mann, R.S., et al. Suppression of histone deacetylation in vivo and in vitro by sodium butyrate. J Biol Chem 253(10) 3364-3366 (1978). Joseph, J., Mudduluru, G., Antony, S., et al. Expression profiling of sodium butyrate (NaB)- Sodium Butyrate is available in the following screening libraries: |
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins. |
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