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N-acetyl-D-Glucosamine

Cayman Chemical Item Number 13136

Marine Sweet; GlcNAc; NSC 524344; NAG (CAS 7512-17-6)

N-acetyl-D-Glucosamine (CAS 7512-17-6)

See more	Alzheimer's Research (48) Signal Transduction (328)

Description

N-acetyl-D-Glucosamine (GlcNAc) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc. Levels of O-GlcNAcylation proteins from Alzheimer’s disease brain extracts are decreased as compared to that in controls, suggesting that release of GlcNAc may contribute to pathogenesis.¹ In E. coli, GlcNAc induces the expression of multidrug exporter genes, indicating that this sugar can alter gene expression.¹ GlcNAc is also the monomeric unit of chitin, which is found in fungi and many invertebrates, including crustaceans, insects, and nematodes. For this reason, chemicals that inhibit the incorporation of GlcNAc into chitin are cytotoxic to these organisms.

1 Liu, F., Iqbal, K., Grundke-Iqbal, I., et al. O-GlnNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer’s disease. Proc Natl Acad Sci USA 101(29) 10804-10809 (2004).

Synonyms	Marine Sweet GlcNAc NSC 524344 NAG
Formal Name	2-(acetylamino)-2-deoxy-D-glucose
CAS Number	7512-17-6
Molecular Formula	C₈H₁₅NO₆
Formula Weight	221.2
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=CC(NC(=O)C)C(O)C(O)[C@H](O)CO

Background Reading

Liu, F., Iqbal, K., Grundke-Iqbal, I., et al. O-GlnNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer’s disease. Proc Natl Acad Sci USA 101(29) 10804-10809 (2004).

Size	Price	Quantity	Subtotal
500 mg	$9.00		$0.00
1 g	$17.00		$0.00
5 g	$72.00		$0.00
10 g	$126.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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