Cayman Chemical | 4-(n-nonyl) Benzeneboronic Acid | Description • 4-Nonylphenylboronic Acid (CAS 256383-45-6)

13140 4-(n-nonyl) Benzeneboronic Acid

4-Nonylphenylboronic Acid (CAS 256383-45-6)

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Fatty acid amide hydrolase (FAAH) is the primary enzyme responsible for the hydrolysis of the endocannabinoid arachidonoyl ethanolamide (AEA). 4-(n-Nonyl)benzeneboronic acid is a potent inhibitor of FAAH, with an IC₅₀ of 9.1 nM.¹ It is also able to inhibit monoacylglycerol lipase (MAGL), which hydrolyzes 2-arachidonoyl glycerol (2-AG), but at ~1000-fold higher concentration (IC₅₀ = 7.9 μM).¹

1 Minkkilä, A., Saario, S.M., Käsnänen, H., et al. Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase. J Med Chem 51 7057-7060 (2008).

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Pricing updated 2010-03-17.
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