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AGK2

Cayman Chemical Item Number 13145

(CAS 304896-28-4)

AGK2 (CAS 304896-28-4)

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Description

Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in cell cycle progression and tumorigenesis. AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC50 = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.1 It rescues dopamine neurons from α-synuclein toxicity in both in vitro and in vivo Parkinson’s disease models, mimicking the effect of siRNA-mediated blockade of SIRT2 expression.1 AGK2 may be a useful tool for studying the roles of SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.

1 Outeiro, T.F., Kontopoulos, E., Altmann, S.M., et al. Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson’s Disease. Science 317 516-519 (2007).

Formal Name 2-​cyano-​3-​[5-​(2,​5-​dichlorophenyl)-​2-​furanyl]-​N-​5-​quinolinyl-​2-​propenamide
CAS Number 304896-28-4
Molecular Formula C23H13Cl2N3O2
Formula Weight 434.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC/C(=C\c1ccc(o1)​c1cc(Cl)​ccc1Cl)​/C(=O)​Nc1cccc2ncccc12

Background Reading

Lee, M.J.C., Shoeman, D.W., Goon, D.J.W., et al. N-hydroxybenzenecarboximidic acid derivatives: A new class of nitroxyl-generating prodrugs. Nitric Oxide 5(3) 278-287 (2001).

AGK2 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $19.00 $0.00
5 mg $86.00 $0.00
10 mg $152.00 $0.00
25 mg $333.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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