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AGK2

Cayman Chemical Item Number 13145

(CAS 304896-28-4)

AGK2 (CAS 304896-28-4)

See more	Inhibitors (493) Cancer (606) Cell Cycle (71) Epigenetics (175) Parkinson's Research (18)

Description

Mammalian sirtuin 2 (SIRT2) is a nicotinamide adenine dinucleotide-dependent histone deacetylase (HDAC) with roles in cell cycle progression and tumorigenesis. AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC₅₀ = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.¹ It rescues dopamine neurons from α-synuclein toxicity in both in vitro and in vivo Parkinson’s disease models, mimicking the effect of siRNA-mediated blockade of SIRT2 expression.¹ AGK2 may be a useful tool for studying the roles of SIRT2 in neurodegeneration and aging, as well as cell cycle progression and tumorigenesis.

1 Outeiro, T.F., Kontopoulos, E., Altmann, S.M., et al. Sirtuin 2 inhibitors rescue a-synuclein-mediated toxicity in models of Parkinson’s Disease. Science 317 516-519 (2007).

Formal Name	2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
CAS Number	304896-28-4
Molecular Formula	C₂₃H₁₃Cl₂N₃O₂
Formula Weight	434.3
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard NC/C(=C\c1ccc(o1)c1cc(Cl)ccc1Cl)/C(=O)Nc1cccc2ncccc12

Background Reading

Lee, M.J.C., Shoeman, D.W., Goon, D.J.W., et al. N-hydroxybenzenecarboximidic acid derivatives: A new class of nitroxyl-generating prodrugs. Nitric Oxide 5(3) 278-287 (2001).

AGK2 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
1 mg	$19.00		$0.00
5 mg	$86.00		$0.00
10 mg	$152.00		$0.00
25 mg	$333.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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