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CAY10603

Cayman Chemical Item Number 13146

(CAS 1045792-66-2)

CAY10603 (CAS 1045792-66-2)

See more	Histone Deacetylase (12) Cancer (606) Cell Biology (281) Epigenetics (175) Gene Regulation (173)

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC₅₀ = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively).¹ Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC₅₀ = 0.1-1 μM).¹ The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

1 Kozikowski, A.P., Tapadar, S., Luchini, D.N., et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem 51 4370-4373 (2008).

Formal Name	N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-1,1-dimethylethyl ester, carbamic acid
CAS Number	1045792-66-2
Molecular Formula	C₂₂H₃₀N₄O₆
Formula Weight	446.5
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ONC(=O)CCCCCCNC(=O)c1noc(c1)c1ccc(cc1)NC(=O)OC(C)(C)C

Background Reading

Kozikowski, A.P., Tapadar, S., Luchini, D.N., et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: A new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem 51 4370-4373 (2008).

CAY10603 is available in the following screening libraries:

Size	Price	Quantity	Subtotal
500 µg	$43.00		$0.00
1 mg	$82.00		$0.00
5 mg	$344.00		$0.00
10 mg	$602.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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