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JZL 184

Cayman Chemical Item Number 13158

(CAS 1101854-58-3)

JZL 184 (CAS 1101854-58-3)

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Sold under license from The Scripps Research Institute.

Description

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide (AEA) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. JZL 184 is a potent and selective inhibitor of MAGL that displays IC50 values of 8 nM and 4 µM for inhibition of MAGL and fatty acid amide hydrolase in mouse brain membranes, respectively.1 When administered to mice at 16 mg/kg, intraperitoneally, JZL 184 reduces MAGL activity by 85%, elevates brain 2-AG levels by 8-fold, and elicits analgesic activity in a variety of pain assays that qualitatively mimics direct central cannabinoid (CB1) agonists.1

1 Long, J.Z., Li, W., Booker, L., et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol 5(1) 37-44 (2009).

Formal Name 4-​nitrophenyl-​4-​(dibenzo[d][1,​3]dioxol-​5-​yl(hydroxy)methyl)piperidine-​1-​carboxylate
CAS Number 1101854-58-3
Molecular Formula C27H24N2O9
Formula Weight 520.2
Formulation A crystalline solid
Purity ≥97%
λmax 284 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC(C1=CC(OCO2)​=C2C=C1)​(C3=CC=C(OCO4)​C4=C3)​C5CCN(C(OC6=CC=C([N+]​([O-]​)​=O)​C=C6)​=O)​CC5

Background Reading

Long, J.Z., Li, W., Booker, L., et al. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol 5(1) 37-44 (2009).

JZL 184 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $29.00 $0.00
10 mg $55.00 $0.00
50 mg $232.00 $0.00
100 mg $406.00 $0.00
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Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Sold under license from The Scripps Research Institute.

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