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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

7(S)-Maresin 1 Exclusive

Cayman Chemical Item Number 13161

7(S)-MaR1 (CAS 1268720-66-6)

7(S)-Maresin 1 (CAS 1268720-66-6)

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Description

Docosahexaenoic acid (DHA) is an ω-3 fatty acid that is abundant in the brain and the retina and is known to be important in early development.1,2 Maresin 1 (7(R)-MaR1) is a 7,14-dihydroxy DHA formed from 14S-hydroperoxy DHA supplied exogenously to resident peritoneal murine macrophages activated with zymosan A.3 It potently reduces infiltration of neutrophils into the murine peritoneum in zymosan A-induced peritonitis when given intravenously (0.2 ng) and significantly increases phagocytosis of FITC-labeled zymosan A by isolated mouse macrophages (0.1-100 nM).3 7(S)-MaR1 is an epimer of the active 7(R)-MaR1.

1 Su, H. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J Nutr Biochem 21 364-373 (2010).

2 Wu, T., and Chen, P. Health consequences of nutrition in childhood and early infancy. Pediatr Neonatol 50(4) 135-142 (2009).

3 Serhan, C.N., Yang, R., Martinod, K., et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med 206 15-23 (2009).

Synonyms
  • 7(S)-MaR1
Formal Name 7S,​14R-​dihydroxy-​4Z,​8E,​10Z,​12Z,​16Z,​19Z-​docosahexaenoic acid
CAS Number 1268720-66-6
Molecular Formula C22H32O4
Formula Weight 360.5
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CC/C=C\C/C=C\CC(O)​/C=C\C=C/C=C\C(O)​C/C=C\CCC(=O)​O

Background Reading

Wu, T., and Chen, P. Health consequences of nutrition in childhood and early infancy. Pediatr Neonatol 50(4) 135-142 (2009).

Su, H. Mechanisms of n-3 fatty acid-mediated development and maintenance of learning memory performance. J Nutr Biochem 21 364-373 (2010).

Serhan, C.N., Yang, R., Martinod, K., et al. Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med 206 15-23 (2009).
Size Price Quantity Subtotal
10 µg $77.00 $0.00
25 µg $183.00 $0.00
50 µg $347.00 $0.00
100 µg $616.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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