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JWH 018 (solution)

Cayman Chemical Item Number 13169

(CAS 209414-07-3)

JWH 018 (solution) (CAS 209414-07-3)

See more	Cannabinoids (333) Forensic Science (369) Neuroscience (725) Pain (151)

Description

JWH 018 is a mildly selective agonist of the peripheral cannabinoid (CB₂) receptor, derived from the aminoalkylindole WIN 55212-2. The K_i values for binding central cannabinoid (CB₁) and CB₂ receptors are 9.0 and 2.94 nM, respectively, for a CB₁:CB₂ ratio of 3.06.¹ Its effects on suppression of spontaneous activity, maximum possible antinociceptive effect in the tail-flick assay, and rectal temperature are comparable to those of WIN 55212-2 when tested in rats.²

1 Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug Alcohol Depend 60 133-140 (2000).

2 Wiley, J.L., Compton, D.R., Dai, D., et al. Structure-activity relationships of indole- and pyrrole-derived cannabinoids. J Pharmacol Exp Ther 285(3) 995-1004 (1998).

Formal Name	(1-pentyl-1H-indol-3-yl)-1-naphthalenyl-methanone
CAS Number	209414-07-3
Molecular Formula	C₂₄H₂₃NO
Formula Weight	341.5
Formulation	A solution in methanol
Purity	≥98%
λ_max	219, 246, 315 nm
Stability	1 year
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CCCCCn1cc(C(=O)c2cccc3ccccc23)c2ccccc12

Background Reading

Wiley, J.L., Compton, D.R., Dai, D., et al. Structure-activity relationships of indole- and pyrrole-derived cannabinoids. J Pharmacol Exp Ther 285(3) 995-1004 (1998).

Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB₁ and CB₂ receptor binding. Drug Alcohol Depend 60 133-140 (2000).

JWH 018 (solution) is available in the following screening library:

Cannabinoid Agonist Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$41.00		$0.00
10 mg	$77.00		$0.00
25 mg	$180.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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(+)-CP 47,497 (solution)

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(−)-CP 55,940

(+)-CP 55,940 Exclusive

(±)-CP 55,940 Exclusive

JWH 007-d₉

JWH 018 2-hydroxyindole metabolite Exclusive

JWH 018 2-hydroxyindole metabolite-d₉ Exclusive

JWH 018 2'-naphthyl-N-(1,1-dimethylpropyl) isomer New Exclusive

JWH 018 2'-naphthyl-N-(1,2-dimethylpropyl) isomer Exclusive

JWH 018 2’-naphthyl-N-(1-ethylpropyl) isomer New Exclusive

JWH 018 2'-naphthyl-N-(1-methylbutyl) isomer Exclusive

JWH 018 2'-naphthyl-N-(2,2-dimethylpropyl) isomer Exclusive

JWH 018 2'-naphthyl-N-(2-methylbutyl) isomer Exclusive

JWH 018 4-hydroxyindole metabolite Exclusive

JWH 018 4-hydroxyindole metabolite-d₉ Exclusive

JWH 018 5-hydroxyindole metabolite Exclusive

JWH 018 5-hydroxyindole metabolite-d₉ Exclusive

JWH 018 6-hydroxyindole metabolite Exclusive

JWH 018 6-hydroxyindole metabolite-d₉ Exclusive

JWH 018 6-methoxyindole analog Exclusive

JWH 018 7-hydroxyindole metabolite Exclusive

JWH 018 7-hydroxyindole metabolite-d₉ Exclusive

JWH 018 adamantyl analog Exclusive

JWH 018-d₉ (solution)

JWH 018 N-(1,1-dimethylpropyl) isomer Exclusive

JWH 018 N-(1,2-dimethylpropyl) isomer Exclusive

JWH 018 N-(1-ethylpropyl) isomer New Exclusive

JWH 018 N-(1-methylbutyl) isomer Exclusive

JWH 018 N-(2,2-dimethylpropyl) isomer Exclusive

(±)-JWH 018 N-(2-hydroxypentyl) metabolite New

JWH 018 N-(4,5-epoxypentyl) analog

(−)-JWH 018 N-(4-hydroxypentyl) metabolite New

(+)-JWH 018 N-(4-hydroxypentyl) metabolite New

(±)-JWH 018 N-(4-hydroxypentyl) metabolite Exclusive

JWH 018 N-(5-bromopentyl) analog New

JWH 018 N-(5-chloropentyl) analog New

JWH 018 N-(5-hydroxypentyl) metabolite Exclusive

JWH 018 N-(5-hydroxypentyl) β-D-Glucuronide New Exclusive

JWH 018 N-pentanoic acid metabolite Exclusive

JWH 018 N-pentanoic acid metabolite-d₄ Exclusive

JWH 019

JWH 022 Exclusive

JWH 030 Exclusive

JWH 073-d₇ (solution) Exclusive

JWH 073 N-butanoic acid metabolite-d₅ Exclusive

JWH 122 N-(5-hydroxypentyl) metabolite Exclusive

JWH 145 Exclusive

JWH 175 New Exclusive

JWH 182 Exclusive

JWH 200 6-hydroxyindole metabolite Exclusive

JWH 200-d₅ (solution)

JWH 309 New Exclusive

JWH 370

MDA 19

(R)-AM1241 Exclusive

RCS-4

RCS-4-C₄ homolog Exclusive

RCS-8

(S)-AM1241 Exclusive

(+)WIN 55212-2 (mesylate)

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