Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…

Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

JWH 200 (solution)

Cayman Chemical Item Number 13171

(CAS 103610-04-4)

JWH 200 (solution) (CAS 103610-04-4)

See more	Cannabinoids (333) Forensic Science (369) Neuroscience (725)

Description

JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor ligand. It binds to the CB₁ receptor with high-affinity (IC₅₀ = 7.8-42 nM).^1,2 The effects of JWH 200 in locomotor activity, tail-flick latency, hypothermia, and ring-immobility tests are comparable or superior to Δ⁹-THC or WIN-55,212.³ It potently inhibits the contraction of electrically-stimulated murine vas deferens (IC₅₀ = 3.7-6.0 nM).^4,5

1 Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J Med Chem 38 3094-3105 (1995).

2 Huffman, J.W., Mabon, R., Wu, M., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor. Bioorg Med Chem 11 539-549 (2003).

3 Compton, D.R., Gold, L.H., Ward, S.J., et al. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from D9-tetrahydrocannabinol. J Pharmacol Exp Ther 263(3) 1118-1126 (1992).

4 Pacheco, M., Childers, S.R., Arnold, R., et al. Aminoalkylindoles: Actions on specific G-protein-linked receptors. J Pharmacol Exp Ther 257(1) 170-183 (1991).

5 Bell, M.R., D'Ambra, T.E., Kumar, V., et al. Antinociceptive (aminoalkyl) indoles. J Med Chem 34 1099-1110 (1991).

Formal Name	[1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number	103610-04-4
Molecular Formula	C₂₅H₂₄N₂O₂
Formula Weight	384.5
Formulation	A solution in acetonitrile
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12

Background Reading

Pacheco, M., Childers, S.R., Arnold, R., et al. Aminoalkylindoles: Actions on specific G-protein-linked receptors. J Pharmacol Exp Ther 257(1) 170-183 (1991).

Bell, M.R., D'Ambra, T.E., Kumar, V., et al. Antinociceptive (aminoalkyl) indoles. J Med Chem 34 1099-1110 (1991).

Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J Med Chem 38 3094-3105 (1995).

Compton, D.R., Gold, L.H., Ward, S.J., et al. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from D9-tetrahydrocannabinol. J Pharmacol Exp Ther 263(3) 1118-1126 (1992).

Huffman, J.W., Mabon, R., Wu, M., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor. Bioorg Med Chem 11 539-549 (2003).

Show all 5 Hide all but first 3

JWH 200 (solution) is available in the following screening library:

Cannabinoid Agonist Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$56.00		$0.00
10 mg	$106.00		$0.00
25 mg	$252.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Featured Products	Mojo
JWH 018 Selective agonist of the CB2 receptor	28.369097520404
JWH 018 (solution) Selective agonist of the CB2 receptor	47.491561336422
JWH 073 Selective agonist of the CB1 receptor	35.953065587533
JWH 073 (solution) Selective agonist of the CB1 receptor	42.977244992795
JWH 200 Potent cannabinoid receptor agonist	23.047589726815
(±)-CP 47,497 A potent CB1 receptor agonist	34.382032339974
(±)-CP 47,497 (solution) A potent CB1 receptor agonist	49.485946899938
(±)-CP 47,497-C8-homolog Exclusive A potent bicyclic CB analog	33.614779595787
(±)-CP 47,497-C8-homolog (solution) Exclusive A potent bicyclic CB analog	43.928671821398
HU-210 A potent synthetic cannabinoid	45.112620856353
HU-210 (solution) A potent synthetic cannabinoid	30.987411207576
Cannabidiol A neuroprotective phenolic compound from marijuana	31.817340173638
Cannabidiol (solution) A neuroprotective phenolic compound from marijuana	45.111998995479
Synthetic Cannabinoid HPLC Mixture II Contains a selection of the most common JWH-, CP-, and HU-series CB receptor agonists	44.388457144890

Related Products

AM694 Exclusive

(±)-CP 47,497-C8-homolog (solution) Exclusive

(−)-CP 47,497 (solution)

(+)-CP 47,497 (solution)

(±)-CP 47,497 (solution)

(−)-CP 55,940

(+)-CP 55,940 Exclusive

(±)-CP 55,940 Exclusive

JWH 018-d₉ (solution)

JWH 018 (solution)

JWH 019

JWH 073-d₇ (solution) Exclusive

JWH 073 (solution)

JWH 098 Exclusive

JWH 122

JWH 175 New Exclusive

JWH 182 Exclusive

JWH 200

JWH 200 4-hydroxyindole metabolite Exclusive

JWH 200 5-hydroxyindole metabolite Exclusive

JWH 200 6-hydroxyindole metabolite Exclusive

JWH 200-d₅ (solution)

JWH 309 New Exclusive

RCS-4

RCS-8

Synthetic Cannabinoid HPLC Mixture I

(+)WIN 55212-2 (mesylate)

Show all 37 Hide all but first 3

Downloads

	Download Product Insert 133 Kb PDF
	Download Material Safety Data Sheet (MSDS) 26 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm
	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.
	For ChemStation-searchable GCMS spectra of many of Cayman’s emerging forensic drug standards see the Cayman Spectral Library (CSL).

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

This product is a DEA exempt preparation of a scheduled compound - no special processing required. For larger quantities or alternate sizes, please contact sales.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs	Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases	Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule	Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640