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JWH 200 (solution)

Cayman Chemical Item Number 13171

(CAS 103610-04-4)

JWH 200 (solution) (CAS 103610-04-4)

See more	Cannabinoids (296) Forensic Science (306) Neuroscience (654)

Description

JWH 200 is an aminoalkylindole that acts as a cannabinoid (CB) receptor ligand. It binds to the CB₁ receptor with high-affinity (IC₅₀ = 7.8-42 nM).^1,2 The effects of JWH 200 in locomotor activity, tail-flick latency, hypothermia, and ring-immobility tests are comparable or superior to Δ⁹-THC or WIN-55,212.³ It potently inhibits the contraction of electrically-stimulated murine vas deferens (IC₅₀ = 3.7-6.0 nM).^4,5

1 Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J Med Chem 38 3094-3105 (1995).

2 Huffman, J.W., Mabon, R., Wu, M., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor. Bioorg Med Chem 11 539-549 (2003).

3 Compton, D.R., Gold, L.H., Ward, S.J., et al. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from D9-tetrahydrocannabinol. J Pharmacol Exp Ther 263(3) 1118-1126 (1992).

4 Pacheco, M., Childers, S.R., Arnold, R., et al. Aminoalkylindoles: Actions on specific G-protein-linked receptors. J Pharmacol Exp Ther 257(1) 170-183 (1991).

5 Bell, M.R., D'Ambra, T.E., Kumar, V., et al. Antinociceptive (aminoalkyl) indoles. J Med Chem 34 1099-1110 (1991).

Formal Name	[1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-1-naphthalenyl-methanone
CAS Number	103610-04-4
Molecular Formula	C₂₅H₂₄N₂O₂
Formula Weight	384.5
Formulation	A solution in acetonitrile
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12

Background Reading

Compton, D.R., Gold, L.H., Ward, S.J., et al. Aminoalkylindole analogs: Cannabimimetic activity of a class of compounds structurally distinct from D9-tetrahydrocannabinol. J Pharmacol Exp Ther 263(3) 1118-1126 (1992).

Huffman, J.W., Mabon, R., Wu, M., et al. 3-indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB₁ cannabinoid receptor. Bioorg Med Chem 11 539-549 (2003).

Eissenstat, M.A., Bell, M.R., D'Ambra, T.E., et al. Aminoalkylindoles: Structure-activity relationships of novel cannabinoid mimetics. J Med Chem 38 3094-3105 (1995).

Pacheco, M., Childers, S.R., Arnold, R., et al. Aminoalkylindoles: Actions on specific G-protein-linked receptors. J Pharmacol Exp Ther 257(1) 170-183 (1991).

Bell, M.R., D'Ambra, T.E., Kumar, V., et al. Antinociceptive (aminoalkyl) indoles. J Med Chem 34 1099-1110 (1991).

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JWH 200 (solution) is available in the following screening library:

Cannabinoid Agonist Screening Library (96-Well)

Size	Price	Quantity	Subtotal
5 mg	$56.00		$0.00
10 mg	$106.00		$0.00
25 mg	$252.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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(+)WIN 55212-2 (mesylate)

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	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

This product is a DEA exempt preparation of a scheduled compound - no special processing required. For larger quantities or alternate sizes, please contact sales.

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