See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!
My Account 
❘ Contact 
❘ Cart 
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.
M 344Cayman Chemical Item Number 13174 D237; Histone Deacetylase Inhibitor III; MS 344 (CAS 251456-60-7) 
M 344 (CAS 251456-60-7)
Description
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM)1 as well as human HDAC1 (IC50 = 46 nM).2 It shows a three-
1 Jung, M., Brosch, G., Kölle, D., et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem 42 4669-4679 (1999). 2 Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem 45(4) 753-757 (2002). 3 Heltweg, B., Dequiedt, F., Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. J Med Chem 47 5235-5243 (2004). 4 Zhang, Y., Jung, M., Dritschilo, A., et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res 161 667-674 (2004). 5 Takai, N., Ueda, T., Nishida, M., et al. M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol Oncol 101 108-113 (2006).
Background ReadingHeltweg, B., Dequiedt, F., Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. J Med Chem 47 5235-5243 (2004). Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem 45(4) 753-757 (2002). Zhang, Y., Jung, M., Dritschilo, A., et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res 161 667-674 (2004). Jung, M., Brosch, G., Kölle, D., et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem 42 4669-4679 (1999). Takai, N., Ueda, T., Nishida, M., et al. M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol Oncol 101 108-113 (2006). Show all 5 Hide all but first 3M 344 is available in the following screening libraries: |
This product is available in custom sizes and/or larger quantities. Please contact our Sales Department for a quote or to purchase. Pricing updated 2012-05-26. Prices are subject to change without notice. To ask for assistance with one of our products please contact a Technical Support Scientist. Warning This product is not for human or veterinary use. Related Products
Downloads
Batch-specific InformationLogin to access batch-specific information |
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins. |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA
Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640
Copyright 2012 Cayman Chemical Company
Quick Search