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M 344Cayman Chemical Item Number 13174 D237; Histone Deacetylase Inhibitor III; MS 344 (CAS 251456-60-7) 
M 344 (CAS 251456-60-7)
Description
M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM)1 as well as human HDAC1 (IC50 = 46 nM).2 It shows a three-
1 Jung, M., Brosch, G., Kölle, D., et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem 42 4669-4679 (1999). 2 Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem 45(4) 753-757 (2002). 3 Heltweg, B., Dequiedt, F., Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. J Med Chem 47 5235-5243 (2004). 4 Zhang, Y., Jung, M., Dritschilo, A., et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res 161 667-674 (2004). 5 Takai, N., Ueda, T., Nishida, M., et al. M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol Oncol 101 108-113 (2006).
Background ReadingZhang, Y., Jung, M., Dritschilo, A., et al. Enhancement of radiation sensitivity of human squamous carcinoma cells by histone deacetylase inhibitors. Radiat Res 161 667-674 (2004). Jung, M., Brosch, G., Kölle, D., et al. Amide analogues of trichostatin A as inhibitors of histone deacetylase and inducers of terminal cell differentiation. J Med Chem 42 4669-4679 (1999). Takai, N., Ueda, T., Nishida, M., et al. M344 is a novel synthesized histone deacetylase inhibitor that induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial cancer and ovarian cancer cells. Gynecol Oncol 101 108-113 (2006). Heltweg, B., Dequiedt, F., Marshall, B.L., et al. Subtype selective substrates for histone deacetylases. J Med Chem 47 5235-5243 (2004). Remiszewski, S.W., Sambucetti, L.C., Atadja, P., et al. Inhibitors of human histone deacetylase: Synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem 45(4) 753-757 (2002). Show all 5 Hide all but first 3M 344 is available in the following screening libraries: |
This product is available in custom sizes and/or larger quantities. Please contact our Sales Department for a quote or to purchase. Pricing updated 2012-02-11. Prices are subject to change without notice. To ask for assistance with one of our products please contact a Technical Support Scientist. Warning This product is not for human or veterinary use. Related Products
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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins. |
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Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA
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