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FKGK 11

Cayman Chemical Item Number 13179

(CAS 1071000-98-0)

FKGK 11 (CAS 1071000-98-0)

See more	Inhibitors (493) Phospholipase (79) Cell Biology (281) Signal Transduction (314)

Description

Phospholipase A₂ (PLA₂) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids, yielding a free fatty acid and a lysophospholipid as products. There are three broad classes of PLA₂, secretory (sPLA₂), calcium-dependent cytosolic (cPLA₂), and calcium-independent cytosolic (iPLA₂), that have different functions. FKGK 11 is a selective inhibitor of iPLA₂ that demonstrates an XI(50) value of 0.0073, where XI(50) equals the mole fraction of FKGK 11 in the total substrate interface required to inhibit iPLA₂ by 50%.¹ In comparison, mole fractions as high as 0.091 do not inhibit cPLA₂ activity and cause only slight inhibition of sPLA₂.¹

1 Baskakis, C., Magrioti, V., Cotton, N., et al. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A₂ enzymes. J Med Chem 51 8027-8037 (2008).

Formal Name	1,1,1,2,2-pentafluoro-7-phenyl-3-heptanone
CAS Number	1071000-98-0
Molecular Formula	C₁₃H₁₃F₅O
Formula Weight	280.2
Formulation	A solution in ethanol
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(C(F)(F)C(F)(F)F)CCCCC1=CC=CC=C1

Background Reading

Baskakis, C., Magrioti, V., Cotton, N., et al. Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A₂ enzymes. J Med Chem 51 8027-8037 (2008).

FKGK 11 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
500 µg	$36.00		$0.00
1 mg	$68.00		$0.00
5 mg	$288.00		$0.00
10 mg	$504.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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