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G-418 Sulfate

Cayman Chemical Item Number 13200

Geneticin (CAS 108321-42-2)

G-418 Sulfate (CAS 108321-42-2)

See more	Molecular Biology (20) Protein Expression (5) Inhibitors (493)

Description

G-418 Sulfate is an aminoglycosidic antibiotic that is related to gentamicin. It is toxic to both prokaryotic and eukaryotic cells, as it blocks protein elongation during translation. G-418 is commonly used for the selection of cells that are genetically engineered with a plasmid containing the neo (neor) gene, which provides resistance to G-418. In mammalian cells, selection is commonly performed using 400 mg/L G-418, followed by 200 mg/L for culture maintenance; optimal concentrations may depend on cell type or plasmid and should be empirically determined.

Synonyms	Geneticin
Formal Name	O-2-amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-sulfate-D-streptamine
CAS Number	108321-42-2
Molecular Formula	C₂₀H₄₀N₄O₁₀ · 2H₂SO₄
Formula Weight	692.2
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard CNC1[C@@H](O)C(OC[C@]1(C)O)OC1[C@H](N)C[C@H](N)C(OC2O[C@H](C(C)O)[C@@H](O)C(O)[C@H]2N)[C@@H]1OOS(=O)(=O)O

Background Reading

Van Nieuwenhoven, F.A., Luiken, J.J.F.P., De Jong, Y.F., et al. Stable transfection of fatty acid translocase (CD36) in a rat heart muscle cell line (H9c2). J Lipid Res 39 2039-2047 (1998).

Size	Price	Quantity	Subtotal
100 mg	$14.00		$0.00
250 mg	$32.00		$0.00
500 mg	$61.00		$0.00
1 g	$84.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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