See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

Agomelatine

Cayman Chemical Item Number 13203

Valdoxan® (CAS 138112-76-2)

Agomelatine (CAS 138112-76-2)

See more

Description

Melatonin, produced in the pineal gland, is an endogenous regulator of circadian rhythms. It acts through the melatonin receptors (MT1 and MT2) and has been shown to have anti-depressant activity in experimental models of clinical depression. Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity.1 However, unlike melatonin, agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6).2 Agomelatine abolishes 5-HT2C agonist effects both in cells and in vivo. It also dose dependently increases extracellular levels of noradrenaline and dopamine in frontal cortex of freely moving rats.2

1 Yous, S., Andrieux, J., Howell, H.E., et al. Novel naphthalenic ligands with high affinity for the melatonin receptor. J Med Chem 35(8) 1484-1486 (1992).

2 Millan, M.J., Gobert, A., Lejeune, F., et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306(3) 954-964 (2003).

Synonyms
  • Valdoxan®
Formal Name N-​[2-​(7-​methoxy-​1-​naphthalenyl)ethyl]-​acetamide
CAS Number 138112-76-2
Molecular Formula C15H17NO2
Formula Weight 243.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
COc1ccc2cccc(CCNC(=O)​C)​c2c1

Background Reading

Yous, S., Andrieux, J., Howell, H.E., et al. Novel naphthalenic ligands with high affinity for the melatonin receptor. J Med Chem 35(8) 1484-1486 (1992).

Millan, M.J., Gobert, A., Lejeune, F., et al. The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306(3) 954-964 (2003).

Agomelatine is available in the following screening library:

Size Price Quantity Subtotal
5 mg $61.00 $0.00
10 mg $116.00 $0.00
50 mg $488.00 $0.00
100 mg $854.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

AFMK
SB 242084 (hydrochloride)

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?