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Holiday Notification: Cayman Chemical will be closed Monday, May 28, 2012, in observance of the Memorial Day holiday. More…
Please feel free to continue placing orders via our website or via fax at 734-971-3640. You may send an email to customer service at custserv@caymanchem.com , or to technical support at techserv@caymanchem.com which we will respond to the next business day. Cayman will resume regular business hours and shipping schedules on Tuesday, May 29, 2012. Thank you for your patience and understanding.

CAY10593 Exclusive

Cayman Chemical Item Number 13206

VU0155069

CAY10593

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Description

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD1 and PLD2, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. CAY10593 is a potent and selective inhibitor of PLD1, both in vitro (IC50 = 46 nM) and in cells (IC50 = 11 nM).1 It is also effective as a PLD2 inhibitor at higher concentrations (IC50 = 933 nM in vitro, 1,800 nM in cells).1 CAY10593 strongly inhibits the invasive migration of several breast cancer cell lines in trans-well assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.1

1 Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 5(2) 108-117 (2009).

Synonyms
  • VU0155069
Formal Name N-​[2-​[4-​(5-​chloro-​2,​3-​dihydro-​2-​oxo-​1H-​benzimidazol-​1-​yl)-​1-​piperidinyl]-​1-​methylethyl]-​2-​naphthalenecarboxamide
Molecular Formula C26H27ClN4O2
Formula Weight 463.0
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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ClC1=CC2=C(N(C3CCN(CC(C)​N([H]​)​C(C4=CC(C=CC=C5)​=C5C=C4)​=O)​CC3)​C(N2[H]​)​=O)​C=C1

Background Reading

Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 5(2) 108-117 (2009).

CAY10593 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $37.00 $0.00
5 mg $167.00 $0.00
10 mg $296.00 $0.00
25 mg $648.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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