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CAY10593 Exclusive

Cayman Chemical Item Number 13206

VU0155069

CAY10593

See more	Inhibitors (493) Cancer (606) Cell Biology (281) Signal Transduction (314)

Description

Phospholipase D (PLD) is an enzyme which cleaves the head group from phospholipids, producing the second messenger phosphatidic acid. Two mammalian isoforms of PLD, PLD₁ and PLD₂, have been identified, with multiple splice variants of each. Although the two isoforms share structural and functional features, they are regulated differently and apparently subserve distinct roles. CAY10593 is a potent and selective inhibitor of PLD₁, both in vitro (IC₅₀ = 46 nM) and in cells (IC₅₀ = 11 nM).¹ It is also effective as a PLD₂ inhibitor at higher concentrations (IC₅₀ = 933 nM in vitro, 1,800 nM in cells).¹ CAY10593 strongly inhibits the invasive migration of several breast cancer cell lines in trans-well assays, suggesting that PLD might be a useful target in blocking tumor cell invasion.¹

1 Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 5(2) 108-117 (2009).

Synonyms	VU0155069
Formal Name	N-[2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl]-2-naphthalenecarboxamide
Molecular Formula	C₂₆H₂₇ClN₄O₂
Formula Weight	463.0
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard ClC1=CC2=C(N(C3CCN(CC(C)N([H])C(C4=CC(C=CC=C5)=C5C=C4)=O)CC3)C(N2[H])=O)C=C1

Background Reading

Scott, S.A., Selvy, P.E., Buck, J.R., et al. Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol 5(2) 108-117 (2009).

CAY10593 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$37.00		$0.00
5 mg	$167.00		$0.00
10 mg	$296.00		$0.00
25 mg	$648.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Downloads

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	Download Material Safety Data Sheet (MSDS) 15 Kb PDF
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	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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