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Mirin

Cayman Chemical Item Number 13208

(CAS 299953-00-7)

Mirin (CAS 299953-00-7)

See more	Inhibitors (546) Cancer (666) Cell Cycle (72)

Description

The Mre11-Rad50-Nbs1 (MRN) complex acts as a DNA damage sensor, maintains genome stability during DNA replication, and activates and recruits ataxia-telangiectasia mutated (ATM) to damaged DNA. The genes that encode the MRN proteins are all essential for cell viability, so functional studies of MRN cannot involve deletion of these genes. Mirin is an inhibitor of MRN, inhibiting MRN-dependent phosphorylation of histone H2AX (IC₅₀ = 66 μM).¹ Through its effects on MRN, mirin prevents activation of ATM. Inhibition of MRN centers on the ability of mirin to block the nuclease activity of Mre11, rather than altering DNA-binding or MRN complex formation. In cells, mirin induces G₂ arrest, abolishes the radiation-induced G₂/M checkpoint, and prevents homology-directed repair of DNA damage.¹

1 Dupré, A., Boyer-Chatenet, L., Sattler, R.M., et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol 4(2) 119-125 (2008).

Formal Name	2-amino-5-[(4-hydroxyphenyl)methylene]-4(5H)-thiazolone
CAS Number	299953-00-7
Molecular Formula	C₁₀H₈N₂O₂S
Formula Weight	220.3
Formulation	An orange crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard N=C(S/C1=C\C2=CC=C(O)C=C2)NC1=O

Background Reading

Dupré, A., Boyer-Chatenet, L., Sattler, R.M., et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol 4(2) 119-125 (2008).

Mirin is available in the following screening libraries:

Size	Price	Quantity	Subtotal
5 mg	$29.00		$0.00
10 mg	$55.00		$0.00
50 mg	$232.00		$0.00
100 mg	$406.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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