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(+)-CP 47,497 (solution)

Cayman Chemical Item Number 13219

(CAS 134308-14-8)

(+)-CP 47,497 (solution) (CAS 134308-14-8)

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Description

CP 47,497 is a bicyclic CB analog with potent analgesic activity.1 It is comparable or more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice, rats, and dogs.2 The dextrorotatory enantiomer, (+)-CP 47,497 avidly binds the CB1 receptor (Ki = 4.15 nM).3

1 Melvin, L.S., Johnson, M.R., Harbert, C.A., et al. A cannabinoid derived prototypical analgesic. J Med Chem 27 67-71 (1984).

2 Weissman, A., Milne, G.M., and Melvin, L.S. Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. J Pharmacol Exp Ther 223(2) 516-523 (1982).

3 Melvin, L.S., Milne, G.M., Johnson, M.R., et al. Structure-activity relationships defining the ACD-tricyclic cannabinoids: Cannabinoid receptor binding and analgesic activity. Drug Design Discov 13 155-166 (1995).

Formal Name 2[(1R,​3S)-​3-​hydroxycyclohexyl]-​5-​(2-​methyloctan-​2-​yl)phenol
CAS Number 134308-14-8
Molecular Formula C21H34O2
Formula Weight 318.5
Formulation A solution in methanol
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1C[C@H]​(C2=CC=C(C(C)​(C)​CCCCCC)​C=C2O)​CCC1

Background Reading

Weissman, A., Milne, G.M., and Melvin, L.S. Jr. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol. J Pharmacol Exp Ther 223(2) 516-523 (1982).

Melvin, L.S., Johnson, M.R., Harbert, C.A., et al. A cannabinoid derived prototypical analgesic. J Med Chem 27 67-71 (1984).

Melvin, L.S., Milne, G.M., Johnson, M.R., et al. Structure-activity relationships defining the ACD-tricyclic cannabinoids: Cannabinoid receptor binding and analgesic activity. Drug Design Discov 13 155-166 (1995).

(+)-CP 47,497 (solution) is available in the following screening library:

Size Price Quantity Subtotal
5 mg $117.00 $0.00
10 mg $208.00 $0.00
25 mg $455.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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(−)-CP 47, 497

A bicyclic cannabinoid analog

12.763946616612
(−)-CP 47,497 (solution)

A bicyclic cannabinoid analog

17.412952685231
(±)-epi CP 47, 497

Epimer of (±)-CP 47,497 for use as an analytical standard

9.598423751790
(±)-epi CP 47,497 (solution) Exclusive

Epimer of (±)-CP 47,497 for use as an analytical standard

9.334116612362
CP 47,497-para-quinone analog Exclusive

Potential metabolite of CP 47,497

12.459427767546
(±)-CP 47,497-C7-hydroxy metabolite

Potential metabolite of CP 47,497

66.972189993861
(±)-CP 47,497-d11 (solution) Exclusive

An internal standard for the quantification of (±)-CP 47,497

34.319074410242

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