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Fumonisin B2

Cayman Chemical Item Number 13227

(CAS 116355-84-1)

Fumonisin B2 (CAS 116355-84-1)

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Description

Fumonisin B2 is a mycotoxin originally isolated from F. moniliforme, a prevalent fungus of corn and other grains.1 Fumonisins cause food poisoning in livestock and humans following the consumption of Fusarium-infested corn.1 Fumonisin B2, like fumonisin B1 (Catalog No. 62580), structurally resembles sphingosine and, at 1 μM, inhibits sphingosine N-acyltransferase (>90%) in hepatocytes.2 Fumonisins induce apoptosis via altered sphingolipid metabolism, resulting in hepatotoxicity and nephrotoxicity. It is now known that fumonisins are produced by fungi other than F. moniliforme and occur as contaminants in a wide variety of foods.

1 Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al. Fumonisins - novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Environ Microbiol 54 1806-1811 (1988).

2 Wang, E., Norred, W.P., Bacon, C.W., et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266 14486-14490 (1991).

Formal Name 1,​1'-​[(1S,​2R)-​1-​[(2S,​9R,​11S,​12S)-​12-​amino-​9,​11-​dihydroxy-​2-​methyltridecyl]-​2-​[(1R)-​1-​methylpentyl]-​1,​2-​ethanediyl]ester-​1,​2,​3-​propanetricarboxylic acid
CAS Number 116355-84-1
Molecular Formula C34H59NO14
Formula Weight 705.8
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC(C)​C(OC(=O)​CC(CC(=O)​O)​C(=O)​O)​C(CC(C)​CCCCCCC(O)​CC(O)​C(C)​N)​OC(=O)​CC(CC(=O)​O)​C(=O)​O

Background Reading

Gelderblom, W.C.A., Jaskiewicz, K., Marasas, W.F.O., et al. Fumonisins - novel mycotoxins with cancer-promoting activity produced by Fusarium moniliforme. Appl Environ Microbiol 54 1806-1811 (1988).

Wang, E., Norred, W.P., Bacon, C.W., et al. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. J Biol Chem 266 14486-14490 (1991).
Size Price Quantity Subtotal
500 µg $85.00 $0.00
1 mg $162.00 $0.00
5 mg $680.00 $0.00
10 mg $1,190.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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