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(±)-CP 55,940 Exclusive

Cayman Chemical Item Number 13241

(CAS 83003-12-7)

(±)-CP 55,940 (CAS 83003-12-7)

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Description

(±)-CP 55,940 was one of the first bicyclic mimetics of Δ9-THC found to have superior analgesic properties.1,2 The racemic mixture of CP 55,940 is 20- to 100-fold more effective than Δ9-THC in altering the reactions to thermal, mechanical and chemical pain in mice (e.g., 50% maximum possible effect (MPE50) observed in the tail clamp assay at 0.46 and 29.1 mg/kg for (±)-CP 55,940 and Δ9-THC, respectively).1 CP 55,940 has also been used to identify and characterize the central cannabinoid (CB1) receptor in rat brain membranes.2 The capacity to displace CP 55,940 from CB1 receptor in rat brain preparations has frequently been used in the characterization of novel cannabimimetics.

1 Howlett, A.C., Johnson, M.R., Melvin, L.S., et al. Nonclassical cannabinoid analgetics inhibit adenylate cyclase: Development of a cannabinoid receptor model. Mol Pharmacol 33 297-302 (1987).

2 Devane, W.A., Dysarz, F.A., Johnson, M.R., et al. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34 605-613 (1988).

Formal Name rel-​2-​((1R,​2R,​5R)-​5-​hydroxy-​2-​(3-​hydroxypropyl)cyclohexyl)-​5-​(2-​methyloctan-​2-​yl)phenol
CAS Number 83003-12-7
Molecular Formula C24H40O3
Formula Weight 376.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@H]​1C[C@@H]​(C2=CC=C(C(C)​(C)​CCCCCC)​C=C2O)​[C@H]​(CCCO)​CC1

Background Reading

Devane, W.A., Dysarz, F.A., Johnson, M.R., et al. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34 605-613 (1988).

Howlett, A.C., Johnson, M.R., Melvin, L.S., et al. Nonclassical cannabinoid analgetics inhibit adenylate cyclase: Development of a cannabinoid receptor model. Mol Pharmacol 33 297-302 (1987).

(±)-CP 55,940 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $55.00 $0.00
10 mg $105.00 $0.00
25 mg $248.00 $0.00
50 mg $440.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Featured ProductsMojo
(+)-CP 55,940 Exclusive

Isomer of CP 55,940

22.036376965575
(−)-CP 55,940

An agonist of CB1 and CB2

42.173747156320
(±)5-epi CP 55,940

By-product of synthesis to be used as analytical standard

8.949804118533

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