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Donepezil

Cayman Chemical Item Number 13245

Aricept^® (CAS 120014-06-4)

Donepezil (CAS 120014-06-4)

See more	Inhibitors (493) Alzheimer's Research (44) Neuroscience (654)

Description

Acetylcholine is a neurotransmitter involved in neural signaling throughout the body. Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.¹ It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.

1 Muñoz-Torrero, D. Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer’s disease. Curr Med Chem 15 2433-2455 (2008).

Synonyms	Aricept®
Formal Name	2,3-dihydro-5,6-dimethoxy-2[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one
CAS Number	120014-06-4
Molecular Formula	C₂₄H₂₉NO₃
Formula Weight	379.5
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41

Background Reading

Mancini, F., Naldi, M., Cavrini, V., et al. Multiwell fluorometric and colorimetric microassays for the evaluation of beta-secretase (BACE-1) inhibitors. Anal Bioanal Chem 388 1175-1183 (2007).

Muñoz-Torrero, D. Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer’s disease. Curr Med Chem 15 2433-2455 (2008).

Rodríguez-Franco, M.I., Fernández-Bachiller, M.I., Pérez, C., et al. Design and synthesis of N-benzylpiperidine-purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase. Bioorg Med Chem 13 6795-6802 (2005).

Size	Price	Quantity	Subtotal
10 mg	$24.00		$0.00
25 mg	$57.00		$0.00
50 mg	$108.00		$0.00
100 mg	$192.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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