See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

YM-58483

Cayman Chemical Item Number 13246

BTP 2 (CAS 223499-30-7)

YM-58483 (CAS 223499-30-7)

See more

Description

Calcium release-activated calcium (CRAC) channels mediate sustained calcium influx in electrically non-excitable cells. CRAC channels are activated by the release of calcium from intracellular stores, as induced by inositol trisphosphate. CRAC channel activation is essential for the activation of leukocytes and the production of cytokines and inflammatory mediators. YM-58483 is a potent inhibitor of CRAC channels, blocking thapsigargin-induced sustained calcium influx, Th2 cytokine production, and NF-AT-driven promoter activity in T lymphocytes (IC50 = 100 nM).1 YM-58483 also inhibits lung interleukin-4 and cysteinyl leukotriene generation as well as airway eosinophil infiltration in animal models of asthma.2

1 Ishikawa, J., Ohga, K., Yoshino, T., et al. A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes. J Immunol 170 4441-4449 (2003).

2 Yoshino, T., Ishikawa, J., Ohga, K., et al. YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models. Eur J Pharmacol 560 225-233 (2007).

Synonyms
  • BTP 2
Formal Name N-​[4-​[3,​5-​bis(trifluoromethyl)-​1H-​pyrazol-​1-​yl]phenyl]-​4-​methyl-​1,​2,​3-​thiadiazole-​5-​carboxamide
CAS Number 223499-30-7
Molecular Formula C15H9F6N5O5
Formula Weight 421.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C(Nc1ccc(cc1)​n1nc(cc1C(F)​(F)​F)​C(F)​(F)​F)​c1snnc1C

Background Reading

Ishikawa, J., Ohga, K., Yoshino, T., et al. A pyrazole derivative, YM-58483, potently inhibits store-operated sustained Ca2+ influx and IL-2 production in T lymphocytes. J Immunol 170 4441-4449 (2003).

Yoshino, T., Ishikawa, J., Ohga, K., et al. YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models. Eur J Pharmacol 560 225-233 (2007).

YM-58483 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $27.00 $0.00
5 mg $122.00 $0.00
10 mg $216.00 $0.00
25 mg $473.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-11. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

YM-201636
YM-53601 Exclusive

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?