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L-DOPA

Cayman Chemical Item Number 13248

3,4-Dihydroxyphenylalanine; Pardopa; Levodopa; Syndopa (CAS 59-92-7)

L-DOPA (CAS 59-92-7)

See more	Neuroscience (725) Parkinson's Research (18)

Description

Dopamine is a neurotransmitter involved in synaptic plasticity, cognition, and the regulation of locomotor control. It is produced endogenously in the substantia nigra and ventral tegmental area but when administered exogenously cannot cross the blood brain barrier. L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier. It is produced from L-tyrosine by trysosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. It is conventionally used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery.¹ However L-DOPA has a short half-life and is known to elevate homocysteine concentrations in plasma, which can be neurotoxic and induce oxidative damage.²

1 Berends, H.I., Nijlant, J.M.M., Movig, K.L.L., et al. The clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke; a Cochrane systematic review. Eur J Phys Rehabil Med 45(4) 621-630 (2009).

2 Müller, T. Possible treatment concepts for the levodopa-related hyperhomocysteinemia. Cardiovasc Psychiatry Neurol 2009 (2009).

Synonyms	3,4-Dihydroxyphenylalanine Pardopa Levodopa Syndopa
Formal Name	3-hydroxy-L-tyrosine
CAS Number	59-92-7
Molecular Formula	C₉H₁₁NO₄
Formula Weight	197.2
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC1=CC(C[C@H](N)C(O)=O)=CC=C1O

Background Reading

Berends, H.I., Nijlant, J.M.M., Movig, K.L.L., et al. The clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke; a Cochrane systematic review. Eur J Phys Rehabil Med 45(4) 621-630 (2009).

Müller, T. Possible treatment concepts for the levodopa-related hyperhomocysteinemia. Cardiovasc Psychiatry Neurol 2009 (2009).

Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats. J Pharm Pharmacol 24 690-695 (1972).

Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA. J Pharmacol Exp Ther 182(1) 130-134 (1972).

Mann, S.P. Assay of tyrosine hydroxylase in tissue homogenates: Effects of Triton-X, sodium, calcium and cyclic AMP. Biochem Pharmacol 29 1593-1595 (1980).

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Size	Price	Quantity	Subtotal
5 g	$14.00		$0.00
25 g	$63.00		$0.00
50 g	$112.00		$0.00
100 g	$196.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-05-26. Prices are subject to change without notice.

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