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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

L-DOPA

Cayman Chemical Item Number 13248

3,4-Dihydroxyphenylalanine; Pardopa; Levodopa; Syndopa (CAS 59-92-7)

L-DOPA (CAS 59-92-7)

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Description

Dopamine is a neurotransmitter involved in synaptic plasticity, cognition, and the regulation of locomotor control. It is produced endogenously in the substantia nigra and ventral tegmental area but when administered exogenously cannot cross the blood brain barrier. L-DOPA is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier. It is produced from L-tyrosine by trysosine hydroxylase and metabolized by catechol-O-methyl transferase (COMT). In the brain L-DOPA is converted to dopamine. It is conventionally used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery.1 However L-DOPA has a short half-life and is known to elevate homocysteine concentrations in plasma, which can be neurotoxic and induce oxidative damage.2

1 Berends, H.I., Nijlant, J.M.M., Movig, K.L.L., et al. The clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke; a Cochrane systematic review. Eur J Phys Rehabil Med 45(4) 621-630 (2009).

2 Müller, T. Possible treatment concepts for the levodopa-related hyperhomocysteinemia. Cardiovasc Psychiatry Neurol 2009 (2009).

Synonyms
  • 3,4-Dihydroxyphenylalanine
  • Pardopa
  • Levodopa
  • Syndopa
Formal Name 3-​hydroxy-​L-​tyrosine
CAS Number 59-92-7
Molecular Formula C9H11NO4
Formula Weight 197.2
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=CC(C[C@H]​(N)​C(O)​=O)​=CC=C1O

Background Reading

Puig, M., Wakade, A.R., and Kirpekar, S.M. Effect of the sympathetic nervous system of chronic treatment with parglyline and l-DOPA. J Pharmacol Exp Ther 182(1) 130-134 (1972).

Yamori, Y., De Jong, W., Yamabe, H., et al. Effects of L-dopa and inhibitors of decarboxylase and monoamine oxidase on brain noradrenaline leves and blood pressure in spontaneously hypertensive rats. J Pharm Pharmacol 24 690-695 (1972).

Mann, S.P. Assay of tyrosine hydroxylase in tissue homogenates: Effects of Triton-X, sodium, calcium and cyclic AMP. Biochem Pharmacol 29 1593-1595 (1980).

Berends, H.I., Nijlant, J.M.M., Movig, K.L.L., et al. The clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke; a Cochrane systematic review. Eur J Phys Rehabil Med 45(4) 621-630 (2009).

Müller, T. Possible treatment concepts for the levodopa-related hyperhomocysteinemia. Cardiovasc Psychiatry Neurol 2009 (2009).

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Size Price Quantity Subtotal
5 g $14.00 $0.00
25 g $63.00 $0.00
50 g $112.00 $0.00
100 g $196.00 $0.00
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Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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