Cayman Chemical | Tamoxifen | Description (CAS 10540-29-1)

13258 Tamoxifen

(CAS 10540-29-1)

Click image to enlarge

• See below for pricing and ordering

• See analysis tools

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

There are two homologous nuclear receptors for the hormone 17β-estradiol (estrogen), commonly called ERα and ERβ. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is a selective estrogen receptor modulator, evoking tissue-dependent effects. It is an antagonist of ER action in breast tissue and breast cancer cells and is reported to be effective in the treatment of early breast cancer to prevent tumor growth.^1,2 Importantly, tamoxifen has been reported to act as an ER agonist in bone and blood vessels, helping to minimize osteoporosis and reduce the risk of cardiovascular disease in post-menopausal women.³ Also, tamoxifen is a partial ER agonist in uterine tissues and is reported to increase the risk of endometrial carcinoma.⁴

1 Horwitz, K.B., McGuire, W.L. Nuclear mechanisms of estrogen action. Effects of estradiol and anti-estrogens on estrogen receptors and nuclear receptor processing. The Journal of Biological Chemistry 253(22) 8185-8191 (1978).

2 Clarke, M., Collins, R., Davies, C., et al. Tamoxifen for early breast cancer: An overview of the randomised trials. Lancet 351 1451-1467 (1998).

3 Tonetti, D.A., Jordan, V.C. Targeted anti-estrogens to treat and prevent diseases in women. Molecular Medicine Today (1996).

4 Jordan, V.C., Assikis, V.J. Endometrial carcinoma and tamoxifen: Clearing up a controversy. Clinical Cancer Research 1 467-472 (1995).

	Download Product Insert 126 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 13258 Tamoxifen

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-19.
Prices are subject to change without notice.

Related Products

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.