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(S)-HDAC-42

Cayman Chemical Item Number 13277

AR42 (CAS 935881-37-1)

(S)-HDAC-42 (CAS 935881-37-1)

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Description

The dysregulation of histone acetylation contributes to the pathogenesis of some cancers. Histone deacetylases (HDACs), which participate in regulating the acetylation status of nucleosomal histones, are increasingly recognized as promising targets for cancer therapy. (S)-HDAC-42 is a potent inhibitor of HDACs (IC50 = 16 nM in vitro).1 It decreases the viability of prostate cancer cell lines (IC50 = 0.40 μM), increasing the expression of p21 and the acetylation of histone H3 while decreasing the phosphorylation of Akt and the expression of Bcl-XL.2 (S)-HDAC-42 also strongly suppresses the growth of PC-3 tumor xenografts, reducing levels of phospho-Akt and Bcl-XL protein in tumors.2

1 Lu, Q., Wang, D., Chen, C., et al. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem 48 5530-5535 (2005).

2 Kulp, S.K., Chen, C., Wang, D., et al. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Clin Cancer Res 12(17) 5199-5206 (2006).

Synonyms
  • AR42
Formal Name N-​[4-​[(hydroxyamino)carbonyl]phenyl]-​αS-​(1-​methylethyl)-​benzeneacetamide
CAS Number 935881-37-1
Molecular Formula C18H20N2O3
Formula Weight 312.4
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C(NC1=CC=C(C(NO)​=O)​C=C1)​[C@@H]​([C@H]​(C)​C)​C2=CC=CC=C2

Background Reading

Kulp, S.K., Chen, C., Wang, D., et al. Antitumor effects of a novel phenylbutyrate-based histone deacetylase inhibitor, (S)-HDAC-42, in prostate cancer. Clin Cancer Res 12(17) 5199-5206 (2006).

Lu, Q., Wang, D., Chen, C., et al. Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem 48 5530-5535 (2005).

(S)-HDAC-42 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $43.00 $0.00
5 mg $194.00 $0.00
10 mg $344.00 $0.00
25 mg $753.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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