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PF-3845

Cayman Chemical Item Number 13279

(CAS 1196109-52-0)

PF-3845 (CAS 1196109-52-0)

See more	Cannabinoids (296) Inhibitors (493) Neuroscience (654) Pain (144)

Description

Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (K_i = 0.23 μM).¹ It covalently binds FAAH on Ser²⁴¹ at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment.¹ PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.¹

1 Ahn, K., Johnson, D.S., Mileni, M., et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol 16 411-420 (2009).

Formal Name	N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
CAS Number	1196109-52-0
Molecular Formula	C₂₄H₂₃F₃N₄O₂
Formula Weight	456.5
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(NC1=CN=CC=C1)N(CC2)CCC2CC3=CC=CC(OC4=NC=C(C(F)(F)F)C=C4)=C3

Background Reading

Ahn, K., Johnson, D.S., Mileni, M., et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol 16 411-420 (2009).

Size	Price	Quantity	Subtotal
1 mg	$22.00		$0.00
5 mg	$99.00		$0.00
10 mg	$176.00		$0.00
25 mg	$385.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Batch-specific Information

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