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CAY10599 Exclusive

Cayman Chemical Item Number 13282

(CAS 1143573-33-4)

CAY10599 (CAS 1143573-33-4)

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Description

Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor γ (PPARγ) agonists with antidiabetic actions in vivo.1,2 The prototypical compound for this class is the TZD rosiglitazone (BRL 49653), which is currently marketed for the treatment of diabetes. CAY10599 is a PPARγ agonist that is 4-fold more potent than rosiglitazone at PPARγ demonstrating an EC50 value of 0.05 µM.3 This compound shows high selectivity for the PPARγ receptor over PPARα (EC50 = 3.99 µM) or PPARδ (EC50 > 10 µM).3

1 Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39 665-668 (1996).

2 Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al. [[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents. J Med Chem 37 3977-3985 (1994).

3 Lin, C., Peng, Y., Coumar, M.S., et al. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor g agonists. J Med Chem 52 2618-2622 (2009).

Formal Name 2-​[[1-​[3-​[4-​([1,​1'-​biphenyl]-​4-​ylcarbonyl)-​2-​propylphenoxy]propyl]-​1,​2,​3,​4-​tetrahydro-​5-​quinolinyl]oxy]-​2-​methyl-​propanoic acid
CAS Number 1143573-33-4
Molecular Formula C38H41NO5
Formula Weight 591.7
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​(C(O)​=O)​OC1=CC=CC2=C1CCCN2CCCOC3=CC=C(C(C4=CC=C(C5=CC=CC=C5)​C=C4)​=O)​C=C3CCC

Background Reading

Cantello, B.C.C., Cawthorne, M.A., Cottam, G.P., et al. [[ω-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents. J Med Chem 37 3977-3985 (1994).

Willson, T.M., Cobb, J.E., Cowan, D.J., et al. The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem 39 665-668 (1996).

Lin, C., Peng, Y., Coumar, M.S., et al. Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor g agonists. J Med Chem 52 2618-2622 (2009).

CAY10599 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
25 mg $805.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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