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Cannabidiol dimethyl ether

Cayman Chemical Item Number 13285

Cannabidiol-2',6'-dimethyl ether; CBDD (CAS 1242-67-7)

Cannabidiol dimethyl ether (CAS 1242-67-7)

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Description

Lipoxygenases (LOs) are non-heme iron-containing dioxygenases that catalyze the oxidation of polyunsaturated fatty acids to generate unsaturated fatty acid hydroperoxides.1 The immediate products of 15-LO fatty acid oxidation act as mediators in inflammation, thrombosis, and cancer.2 CBDD is a cannabidiol derivative that potently and selectively inhibits 15-LO with an IC50 value of 0.28 µM.3 It does not inhibit 5-LO effectively (IC50 >200 µM).3

1 Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).

2 Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).

3 Takeda, S., Usami, N., Yamamoto, I., et al. Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metab Dispos (2009).

Synonyms
  • Cannabidiol-2',6'-dimethyl ether
  • CBDD
Formal Name 1,​3-​dimethoxy-​2-​[(1R,​6R)-​3-​methyl-​6-​(1-​methylethenyl)-​2-​cyclohexen-​1-​yl]-​5-​pentyl-​benzene
CAS Number 1242-67-7
Molecular Formula C23H34O2
Formula Weight 342.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCc1cc(OC)​c(c(OC)​c1)​[C@@H]​1C=C(C)​CCC1C(=C)​C

Background Reading

Argentieri, D.C., Ritchie, D.M., Ferro, M.P., et al. Tepoxalin: A dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile. J Pharmacol Exp Ther 271 1399-1408 (1994).

Takeda, S., Usami, N., Yamamoto, I., et al. Cannabidiol-2',6'-dimethyl ether, a cannabidiol derivative, is a highly potent and selective 15-lipoxygenase inhibitor. Drug Metab Dispos (2009).

Hope, W.C., Welton, A.F., Fiedler-Nagy, C., et al. In vitro inhibition of the biosynthesis of slow reacting substance of anaphylaxis (SRS-A) and lipoxygenase activity by quercetin. Biochem Pharmacol 32 367-371 (1983).

Cannabidiol dimethyl ether is available in the following screening library:

Size Price Quantity Subtotal
1 mg $25.00 $0.00
5 mg $113.00 $0.00
10 mg $200.00 $0.00
50 mg $875.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

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Quercetin
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