See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

FK-866

Cayman Chemical Item Number 13287

K 22.175 (CAS 658084-64-1)

FK-866 (CAS 658084-64-1)

See more

Description

Nicotinamide phosphoribosyltransferase (NAMPT) catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate step in the biosynthesis of nicotinamide adenine dinucleotide (NAD+). FK-866 is a highly specific non-competitive inhibitor of NAMPT (Ki = 0.4 nM), causing gradual NAD+ depletion.1 In Hep-G2 human liver carcinoma cells, NAD+ depletion by FK-866 directs delayed cell death by apoptosis (IC50 = ~1 nM).1 In normal human smooth muscle cells, FK-866 causes premature senescence, an effect that may be linked to decreased activity of the NAD+-dependent enzyme SIRT1.2 Also, FK-866 induces autophagy in SH-SY5Y neuroblastoma cells, as indicated by the formation of LC3-positive vesicles.3

1 Hasmann, M., and Schemainda, I. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 63 7436-7442 (2003).

2 van der Veer, E., Ho, C., O'Neil, C., et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem 282(15) 10841-10845 (2007).

3 Billington, R.A., Genazzani, A.A., Travelli, C., et al. NAD depletion by FK866 induces autophagy. Autophagy 4(3) 385-387 (2008).

Synonyms
  • K 22.175
Formal Name N-​[4-​(1-​benzoyl-​4-​piperidinyl)butyl]-​3-​(3-​pyridinyl)-​2E-​propenamide
CAS Number 658084-64-1
Molecular Formula C24H29N3O2
Formula Weight 391.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C(N1CCC(CCCCNC(/C=C/C2=CN=CC=C2)​=O)​CC1)​C3=CC=CC=C3

Background Reading

van der Veer, E., Ho, C., O'Neil, C., et al. Extension of human cell lifespan by nicotinamide phosphoribosyltransferase. J Biol Chem 282(15) 10841-10845 (2007).

Hasmann, M., and Schemainda, I. FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis. Cancer Res 63 7436-7442 (2003).

Billington, R.A., Genazzani, A.A., Travelli, C., et al. NAD depletion by FK866 induces autophagy. Autophagy 4(3) 385-387 (2008).
Size Price Quantity Subtotal
5 mg $122.00 $0.00
10 mg $232.00 $0.00
25 mg $549.00 $0.00
50 mg $976.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-10. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Autophagy/Cytotoxicity Dual Staining Kit
CAY10618 Exclusive
SIRT1 Direct Fluorescent Screening Assay Kit
SIRT1 FRET-Based Screening Assay Kit
SIRT1 (human recombinant)
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Login to access batch-specific information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

Other Resources
Management Team Company Profile Company History ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2012 Cayman Chemical Company

Lost password?