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Bisindolylmaleimide IV

Cayman Chemical Item Number 13299

Arcyriarubin A (CAS 119139-23-0)

Bisindolylmaleimide IV (CAS 119139-23-0)

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Description

Bisindolylmaleimide IV is a cell permeable inhibitor of protein kinase C (PKC) with IC50 values reported to range from 0.10 to 0.55 µM.1,2,3,4 Bisindolylmaleimide IV was designed to be more discriminative than its parent compound, the non-selective PKC inhibitor, staurosporine (Catalog No. 81590). However, bisindolylmaleimide IV also inhibits protein kinase A with IC50 values ranging from 2 to 11.8 µM.1,2

1 Davis, P.D., Hill, C.H., Lawton, G., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. J Med Chem 35 177-184 (1992).

2 Toullec, D., Pianetti, P., Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266(24) 15771-15781 (1991).

3 Fabre, S., and Prudhomme, M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem 1(3) 193-196 (1993).

4 Lazareno, S., Popham, A., and Birdsall, N.J.M. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol 360 281-284 (1998).

Synonyms
  • Arcyriarubin A
Formal Name 3,​4-​di-​1H-​indol-​3-​yl-​1H-​pyrrole-​2,​5-​dione
CAS Number 119139-23-0
Molecular Formula C20H13N3O2
Formula Weight 327.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1NC(=O)​C(=C1c1c[nH]​c2ccccc12)​c1c[nH]​c2ccccc12

Background Reading

Davis, P.D., Hill, C.H., Lawton, G., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. J Med Chem 35 177-184 (1992).

Toullec, D., Pianetti, P., Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266(24) 15771-15781 (1991).

Fabre, S., and Prudhomme, M. Protein kinase C inhibitors; structure-activity relationships in K252c-related compounds. Bioorg Med Chem 1(3) 193-196 (1993).

Lazareno, S., Popham, A., and Birdsall, N.J.M. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol 360 281-284 (1998).

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Bisindolylmaleimide IV is available in the following screening library:

Size Price Quantity Subtotal
1 mg $41.00 $0.00
5 mg $185.00 $0.00
10 mg $328.00 $0.00
25 mg $718.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Staurosporine
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