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Ro 31-6045

Cayman Chemical Item Number 13300

Bisindolylmaleimide V (CAS 113963-68-1)

Ro 31-6045 (CAS 113963-68-1)

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Description

Ro 31-6045 is a weak inhibitor of protein kinase C (PKC) demonstrating an IC50 value >100 µM.1,2,3 While effectively inactive as a PKC inhibitor, Ro 31-6045 blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 µM.4

1 Lazareno, S., Popham, A., and Birdsall, N.J.M. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol 360 281-284 (1998).

2 Toullec, D., Pianetti, P., Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266(24) 15771-15781 (1991).

3 Davis, P.D., Hill, C.H., Lawton, G., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. J Med Chem 35 177-184 (1992).

4 Marmy-Conus, N., Hannan, K.M., and Pearson, R.B. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k : Implications for the analysis of S6K signalling. FEBS Lett 519 135-140 (2002).

Synonyms
  • Bisindolylmaleimide V
Formal Name 3,​4-​di-​1H-​indol-​3-​yl-​1-​methyl-​1H-​pyrrole-​2,​5-​dione
CAS Number 113963-68-1
Molecular Formula C21H15N3O2
Formula Weight 341.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1C(=C(c2c[nH]​c3ccccc23)​C(=O)​N1C)​c1c[nH]​c2ccccc12

Background Reading

Toullec, D., Pianetti, P., Coste, H., et al. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266(24) 15771-15781 (1991).

Davis, P.D., Hill, C.H., Lawton, G., et al. Inhibitors of protein kinase C. 1.1 2,3-bisarylmaleimides. J Med Chem 35 177-184 (1992).

Lazareno, S., Popham, A., and Birdsall, N.J.M. Muscarinic interactions of bisindolylmaleimide analogues. Eur J Pharmacol 360 281-284 (1998).

Marmy-Conus, N., Hannan, K.M., and Pearson, R.B. Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k : Implications for the analysis of S6K signalling. FEBS Lett 519 135-140 (2002).

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Ro 31-6045 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
25 mg $893.00 $0.00
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Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Bisindolylmaleimide I
Bisindolylmaleimide IV
Bisindolylmaleimide XI (hydrochloride) New
Ro 31-7549 (acetate)
Ro 31-8220 (mesylate)
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