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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

NU 7026

Cayman Chemical Item Number 13308

DNA-PK Inhibitor II; LY293646 (CAS 154447-35-5)

NU 7026 (CAS 154447-35-5)

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Description

DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).1 It poorly inhibits phosphioinositide 3 kinase (IC50 = 13 μM) and is inactive against ataxia telangiectasia mutated kinase, ATR, and poly (ADP-ribose) polymerase.1 NU 7026 impairs cellular DNA double strand break repair and decreases survival in cells exposed to ionizing radiation.1 It also potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. For example, it potentiates the growth inhibitory effects of mitoxantrone in K562 cells more than 10-fold.2

1 Veuger, S.J., Curtin, N.J., Richardson, C.J., et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res 63 6008-6015 (2003).

2 Willmore, E., de Caux, S., Sunter, N.J., et al. Anovel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood 103(12) 4659-4665 (2004).

Synonyms
  • DNA-PK Inhibitor II
  • LY293646
Formal Name 2-​(4-​morpholinyl)-​4H-​naphtho[1,​2-​b]pyran-​4-​one
CAS Number 154447-35-5
Molecular Formula C17H15NO3
Formula Weight 281.3
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=c1cc(oc2c1ccc1ccccc21)​N1CCOCC1

Background Reading

Willmore, E., de Caux, S., Sunter, N.J., et al. Anovel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood 103(12) 4659-4665 (2004).

Veuger, S.J., Curtin, N.J., Richardson, C.J., et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1. Cancer Res 63 6008-6015 (2003).
Size Price Quantity Subtotal
5 mg $65.00 $0.00
10 mg $124.00 $0.00
25 mg $293.00 $0.00
50 mg $520.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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