Cayman Chemical | KN-62 | Description (CAS 127191-97-3)

13318 KN-62

(CAS 127191-97-3)

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KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC₅₀ = 900 nM).¹ It does not affect the activity of several other kinases when tested at 10 µM.² KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC₅₀ = 15 nM).³

1 Tokunitsu, H., Chijiwa, T., Hagiwara, M., et al. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific Inhibitor of Ca²⁺/calmodulin-dependent protein kinase II. J Biol Chem 265(8) 4315-4320 (1990).

2 Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351 95-105 (2000).

3 Chessell, I.P., Michel, A.D., Humphrey, P.P.A. Effects of antagonists at the human recombinant P2X7 receptor. Brit J Pharmacol 124 1314-1320 (1998).

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Pricing updated 2010-02-09.
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