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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

KN-62

Cayman Chemical Item Number 13318

(CAS 127191-97-3)

KN-62 (CAS 127191-97-3)

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Description

KN-62 is a selective, cell permeable inhibitor of calcium/calmodulin-dependent kinase II (CaMKII; IC50 = 900 nM).1 It does not affect the activity of several other kinases when tested at 10 µM.2 KN-62 also acts as a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM).3

1 Tokunitsu, H., Chijiwa, T., Hagiwara, M., et al. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific Inhibitor of Ca2+/calmodulin-dependent protein kinase II. J Biol Chem 265(8) 4315-4320 (1990).

2 Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351 95-105 (2000).

3 Chessell, I.P., Michel, A.D., and Humphrey, P.P.A. Effects of antagonists at the human recombinant P2X7 receptor. Br J Pharmacol 124 1314-1320 (1998).

Formal Name 4-​[(2S)-​2-​[(5-​isoquinolinylsulfonyl)methylamino]-​3-​oxo-​3-​(4-​phenyl-​1-​piperazinyl)propyl]phenyl ester,​ 5-​isoquinolinesulfonic acid
CAS Number 127191-97-3
Molecular Formula C38H35N5O6S2
Formula Weight 721.9
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CN([C@@H]​(CC1=CC=C(OS(=O)​(C2=C3C(C=NC=C3)​=CC=C2)​=O)​C=C1)​C(N4CCN(C5=CC=CC=C5)​CC4)​=O)​S(C6=CC=CC7=C6C=CN=C7)​(=O)​=O

Background Reading

Chessell, I.P., Michel, A.D., and Humphrey, P.P.A. Effects of antagonists at the human recombinant P2X7 receptor. Br J Pharmacol 124 1314-1320 (1998).

Davies, S.P., Reddy, H., Caivano, M., et al. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351 95-105 (2000).

Tokunitsu, H., Chijiwa, T., Hagiwara, M., et al. KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine, a specific Inhibitor of Ca2+/calmodulin-dependent protein kinase II. J Biol Chem 265(8) 4315-4320 (1990).

KN-62 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $42.00 $0.00
5 mg $189.00 $0.00
10 mg $336.00 $0.00
25 mg $735.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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