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SB 225002

Cayman Chemical Item Number 13336

(CAS 182498-32-4)

SB 225002 (CAS 182498-32-4)

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Description

CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM.1 SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC50 = 30 nM).1 Similarly, SB225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.2

1 White, J.R., Lee, J.M., Young, P.R., et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 273(17) 10095-10098 (1998).

2 Bento, A.F., Leite, D.F.P., Claudino, R.F., et al. The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. J Leukoc Biol 84 1213-1221 (2008).

Formal Name N-​(2-​bromophenyl)-​N'-​(2-​hydroxy-​4-​nitrophenyl)-​urea
CAS Number 182498-32-4
Molecular Formula C13H10BrN3O4
Formula Weight 352.1
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=CC([N+]​([O-]​)​=O)​=CC=C1NC(NC2=C(Br)​C=CC=C2)​=O

Background Reading

White, J.R., Lee, J.M., Young, P.R., et al. Identification of a potent, selective non-peptide CXCR2 antagonist that inhibits interleukin-8-induced neutrophil migration. J Biol Chem 273(17) 10095-10098 (1998).

Bento, A.F., Leite, D.F.P., Claudino, R.F., et al. The selective nonpeptide CXCR2 antagonist SB225002 ameliorates acute experimental colitis in mice. J Leukoc Biol 84 1213-1221 (2008).

SB 225002 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $66.00 $0.00
10 mg $125.00 $0.00
25 mg $297.00 $0.00
50 mg $528.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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