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GYY 4137 Exclusive

Cayman Chemical Item Number 13345

(CAS 106740-09-4)

GYY 4137 (CAS 106740-09-4)

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Description

Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor.1 When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models.1 Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.2

1 Li, L., Whiteman, M., Guan, Y.Y., et al. Characterization of a novel, water-soluble hydrogen sulfide releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide. Circulation 117 2351-2360 (2008).

2 Li, L., Salto-Tellez, M., Tan, C., et al. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic Biol Med 47 103-113 (2009).

Formal Name (p-​methoxyphenyl)morpholino-​phosphinodithioic acid
CAS Number 106740-09-4
Molecular Formula C11H16NO2PS2 · C4H10NO
Formula Weight 377.5
Formulation A crystalline solid
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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COc1ccc(cc1)​P(=S)​([S-]​)​N1CCOCC1.C1COCC[NH2+]​1

Background Reading

Li, L., Salto-Tellez, M., Tan, C., et al. GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat. Free Radic Biol Med 47 103-113 (2009).

Li, L., Whiteman, M., Guan, Y.Y., et al. Characterization of a novel, water-soluble hydrogen sulfide releasing molecule (GYY4137): New insights into the biology of hydrogen sulfide. Circulation 117 2351-2360 (2008).
Size Price Quantity Subtotal
10 mg $47.00 $0.00
25 mg $112.00 $0.00
50 mg $212.00 $0.00
100 mg $376.00 $0.00
Bulk Contact
Cart Total $0.00

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Pricing updated 2012-05-26. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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