Cayman Chemical | Rapamycin | Description • Sirolimus (CAS 53123-88-9)

13346 Rapamycin

Sirolimus (CAS 53123-88-9)

Click image to enlarge

• See below for pricing and ordering

• See analysis tools

• See more Inhibitors; Cancer; Cell Biology; Diabetes; Immunology; Obesity; Signal Transduction

Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Rapamycin is an immunosuppressant that is used primarily to prevent the rejection of organ and bone marrow transplant. It was first described as a potent inhibitor of IL-2 activation of lymphocytes (IC₅₀ = 5 pM).¹ It is now known that rapamycin specifically interacts with the cytosolic FK-binding protein 12 (FKBP12) to form a complex which inhibits the mammalian target of rapamycin (mTOR) pathway by directly binding to mTOR Complex 1 (mTORC1). Rapamycin and other inhibitors of mTORC1 signaling show potential in treating cancer, adipogenesis, diabetes, tuberous sclerosis, and cardiovascular disease.^2,3,4

1 Kay, J.E., Kromwel, L., Doe, S.E.A., et al. Inhibition of T and B lymphocyte proliferation by rapamycin. Immunology 72 544-549 (1991).

2 Akcakanat, A., Zhang, L., Tsavachidis, S., et al. The rapamycin-regulated gene expression signature determines prognosis for breast cancer. Molecular Cancer (2009).

3 Zhang, H.H., Huang, J., Düvel, K., et al. Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway. PLoS One (2009).

4 Balgi, A.D., Fonseca, B.D., Donohue, E., et al. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS One (2009).

	Download Product Insert 85 Kb PDF
	Download Material Safety Data Sheet (MSDS) 17 Kb PDF
	Printer-friendly version of this page small PDF (usually less than 100 Kb)
	• US Letter paper 8½″ × 11″
	• A4 paper 21cm × 29.7cm

Purchase 13346 Rapamycin

Pricing is for North America only. Other customers should contact a distributor in their region.

This product is also available to buy in bulk quantities. Please contact our Sales Department for a quote or to purchase.

Cayman strives to be a reliable biochemical reagent vendor by providing the best possible products and services. To ask for assistance with one of our products please contact our Technical Help staff.

Warning This product is not for human or veterinary use.

Pricing updated 2010-03-17.
Prices are subject to change without notice.

Related Products

Stability of this item is suitable for room temperature overnight shipping. If shipment on ice is desired, it must be requested when the order is placed.