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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

IBMX

Cayman Chemical Item Number 13347

NSC 165960; 1-Methyl-3-Isobutylxanthine; Isobutylmethylxanthine (CAS 28822-58-4)

IBMX (CAS 28822-58-4)

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Description

IBMX is a widely-used non-specific inhibitor of cyclic AMP (cAMP) and cyclic GMP (cGMP) phosphodiesterases (PDEs) (IC50 = 19, 50, 18, 13, 32, 7, and 50 μM for PDE1, PDE2, PDE3, PDE4, PDE5, PDE7, and PDE11, respectively). PDE8A, PDE8B, and PDE9 are insensitive to IBMX.1 By inhibiting PDEs, IBMX increases cellular cAMP and cGMP levels, activating cyclic-nucleotide-regulated protein kinases. Methylxanthines, including IBMX, caffeine, and theophylline, bind adenosine receptors,typically antagonizing the suppressive effects of natural agonists.2

1 Fawcett, L., Baxendale, R., Stacey, P., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA 97(7) 3702-3707 (2000).

2 Snyder, S.H., Katims, J.J., Annau, Z., et al. Adenosine receptors and behavioral actions of methylxanthines [caffeine/theophylline/N6-cyclohexyladenosine/N6-(phenylisopropyl)adenosine]. Proc Natl Acad Sci USA 78(5) 3260-3264 (1981).

Synonyms
  • NSC 165960
  • 1-Methyl-3-Isobutylxanthine
  • Isobutylmethylxanthine
Formal Name 3,​9-​dihydro-​1-​methyl-​3-​(2-​methylpropyl)-​1H-​purine-​2,​6-​dione
CAS Number 28822-58-4
Molecular Formula C10H14N4O2
Formula Weight 222.3
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CC(C)​CN(C1=C2NC=N1)​C(N(C)​C2=O)​=O

Background Reading

Fawcett, L., Baxendale, R., Stacey, P., et al. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci USA 97(7) 3702-3707 (2000).

Snyder, S.H., Katims, J.J., Annau, Z., et al. Adenosine receptors and behavioral actions of methylxanthines [caffeine/theophylline/N6-cyclohexyladenosine/N6-(phenylisopropyl)adenosine]. Proc Natl Acad Sci USA 78(5) 3260-3264 (1981).

IBMX is available in the following screening library:

Size Price Quantity Subtotal
50 mg $16.00 $0.00
100 mg $29.00 $0.00
250 mg $64.00 $0.00
500 mg $96.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Cyclic AMP EIA Kit
Cyclic GMP EIA Kit
Rolipram

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