Myristic acid is a 14-carbon saturated (14:0) fatty acid. In vivo, it is commonly added covalently to the N-terminus of proteins in a co-translational process termed N-myristoylation.1 In addition, there are examples where N-myristoylation occurs post-translationally, when a hidden myristoylation pattern is exposed.2
1
Farazi, T.A., Waksman, G., and Gordon, J.I. The biology and enzymology of protein N-myristoylation. J Biol Chem276(43)39501-39504(2001).
2
Zha, J., Weiler, S., Oh, K.J., et al. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science2901761-1765(2000).
Synonyms
NSC 5028
Formal Name
tetradecanoic acid
CAS Number
544-63-8
Molecular Formula
C14H28O2
Formula Weight
228.4
Formulation
A crystalline solid
Purity
≥98%
Stability
2 years
Storage
-20°C
Shipping
Wet ice
in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCC(O)=O
Background Reading
Farazi, T.A., Waksman, G., and Gordon, J.I. The biology and enzymology of protein N-myristoylation. J Biol Chem276(43)39501-39504(2001).
Zha, J., Weiler, S., Oh, K.J., et al. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science2901761-1765(2000).
Myristic Acid is available in the following screening
library: