Hexacosanoic acid is a 26-carbon saturated (26:0) fatty acid. Elevated plasma levels of saturated very-long-chain fatty acids and in particular hexacosanoic acid, are found in peroxisomal disorders including adrenoleukodystrophy.1 Increased levels of hexacosanoic acid in red blood cells or in plasma may also be associated with atherosclerosis2 and metabolic syndrome,3 respectively.
1
Kobayashi, T., Shinnoh, N., Kondo, A., et al. Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism. Biochem Biophys Res Commun232631-636(1997).
2
Antoku, Y., Tsukamoto, K., Miyoshi, Y., et al. Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis. Atherosclerosis153169-173(2000).
3
Kume, A., Miyazaki, T., Kitamura, Y., et al. High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. Diabetes Res Clin Pract80259-264(2008).
Synonyms
Cerotic Acid
NSC 4205
Ceric Acid
Formal Name
hexacosanoic acid
CAS Number
506-46-7
Molecular Formula
C26H52O2
Formula Weight
396.7
Formulation
A crystalline solid
Purity
≥98%
Stability
2 years
Storage
-20°C
Shipping
Wet ice
in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCCCCCCCCCCC(O)=O
Background Reading
Kobayashi, T., Shinnoh, N., Kondo, A., et al. Adrenoleukodystrophy protein-deficient mice represent abnormality of very long chain fatty acid metabolism. Biochem Biophys Res Commun232631-636(1997).
Antoku, Y., Tsukamoto, K., Miyoshi, Y., et al. Correlations of elevated levels of hexacosanoate in erythrocyte membranes with risk factors for atherosclerosis. Atherosclerosis153169-173(2000).
Kume, A., Miyazaki, T., Kitamura, Y., et al. High levels of saturated very long-chain fatty acid (hexacosanoic acid; C26:0) in whole blood are associated with metabolic syndrome in Japanese men. Diabetes Res Clin Pract80259-264(2008).
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