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Join us! · InformexUSA 2012 · New Orleans, Louisiana · February 14-17, 2012 · Booth 2514

8-iso Prostaglandin E1

Cayman Chemical Item Number 13360

Ovinonic acid; 8-iso PGE1; 8-epi PGE1 (CAS 21003-46-3)

8-iso Prostaglandin E1 (CAS 21003-46-3)

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Description

Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin.1 8-iso Prostaglandin E1 (8-iso PGE1) is an isoprostane which is found in human semen at levels of 7 µg/ml.2 It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF2α.3

1 Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

2 Taylor, P.L. The 8-isoprostaglandins: Evidence for eight compounds in human semen. Prostaglandins 17 259-267 (1979).

3 Nakano, J., and Kessinger, J.M. Effects of 8-isoprostaglandin E1 on the systemic and pulmonary circulations in dogs. Proc Soc Exp Biol Med 133 1314-1317 (1970).

Synonyms
  • Ovinonic acid
  • 8-iso PGE1
  • 8-epi PGE1
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​(8β)-​prost-​13E-​en-​1-​oic acid
CAS Number 21003-46-3
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A light yellow crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=C1[C@@H]​(CCCCCCC(O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1

Background Reading

Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

Nakano, J., and Kessinger, J.M. Effects of 8-isoprostaglandin E1 on the systemic and pulmonary circulations in dogs. Proc Soc Exp Biol Med 133 1314-1317 (1970).

Taylor, P.L. The 8-isoprostaglandins: Evidence for eight compounds in human semen. Prostaglandins 17 259-267 (1979).

Ohno, H., Morikawa, Y., and Hirata, F. Studies on 15-hydroxyprostaglandin dehydrogenase with various prostaglandin analogues. J Biochem 84 1485-1494 (1978).

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8-iso Prostaglandin E1 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $34.00 $0.00
1 mg $65.00 $0.00
5 mg $272.00 $0.00
10 mg $476.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

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Pricing updated 2012-02-12. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

8-iso Prostaglandin F2α
Prostaglandin E1
Prostaglandin F2α

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