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Piroxicam

Cayman Chemical Item Number 13368

NSC 666076; Larapam; Feldene (CAS 36322-90-4)

Piroxicam (CAS 36322-90-4)

See more	Inhibitors (493) NSAIDS (24) Arthritis (32) Cancer (606) Inflammation (383) Pain (144)

Description

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) that non-selectively and reversibly inhibits both isoforms of cyclooxygenase (COX; IC₅₀ = 1.57 and 1.69 μM for COX-1 and COX-2, respectively).¹ It has an extended half-life of about 40 hours, which allows once daily administration leading to sustained plasma and tissue levels. In addition to its anti-inflammatory effects, piroxicam is known to be an effective analgesic that has been used extensively in the treatment of arthritis. It has also been used to inhibit COX activity for treatment of certain cancers in animals. As with other NSAIDs, the extended use of piroxicam results in damage to the gastrointestinal lining.

1 Pairet, M., van Ryn, J., Schierok, H., et al. Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4'-isomer. Inflamm Res 47 270-276 (1998).

Synonyms	NSC 666076 Larapam Feldene
Formal Name	4-hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide
CAS Number	36322-90-4
Molecular Formula	C₁₅H₁₃N₃O₄S
Formula Weight	331.4
Formulation	A crystalline solid
Purity	≥95%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard O=C(C(N1C)=C(O)C2=CC=CC=C2S1(=O)=O)NC3=CC=CC=N3

Background Reading

Pairet, M., van Ryn, J., Schierok, H., et al. Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4'-isomer. Inflamm Res 47 270-276 (1998).

Size	Price	Quantity	Subtotal
500 mg	$15.00		$0.00
1 g	$29.00		$0.00
5 g	$120.00		$0.00
10 g	$210.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-11. Prices are subject to change without notice.

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