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CAY10606

Cayman Chemical Item Number 13381

(CAS 1159576-98-3)

CAY10606 (CAS 1159576-98-3)

See more	Inhibitors (493) Allergy/Asthma (97) Cell Biology (281) Inflammation (383)

Description

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC₅₀ = 86 nM) and in intact neutrophils (IC₅₀ = 230 nM).¹ It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC₅₀ = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC₅₀ = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.¹

1 Karg, E., Luderer, S., Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem 52 3474-3483 (2009).

Formal Name	2-[(3-chlorophenyl)methyl]-5-hydroxy-1H-benz[g]indole-3-carboxylic acid, ethyl ester
CAS Number	1159576-98-3
Molecular Formula	C₂₂H₁₈ClNO₃
Formula Weight	379.8
Formulation	A crystalline solid
Purity	≥98%
Stability	2 years
Storage	-20°C
Shipping	Room temperature in continental US; may vary elsewhere
SMILES	Copy SMILES to clipboard OC1=CC2=C(NC(CC3=CC=CC(Cl)=C3)=C2C(OCC)=O)C4=C1C=CC=C4

Background Reading

Karg, E., Luderer, S., Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem 52 3474-3483 (2009).

CAY10606 is available in the following screening library:

Bio-active Lipid I Screening Library (96-Well)

Size	Price	Quantity	Subtotal
1 mg	$86.00		$0.00
5 mg	$387.00		$0.00
10 mg	$688.00		$0.00
25 mg	$1,505.00		$0.00
Bulk	Contact
		Cart Total	$0.00

Pricing updated 2012-02-12. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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	Chemical structure definitions are available for many Cayman products. See Chemical Structure Database for details.

Batch-specific Information

Cayman Chemical is a manufacturer, supplier and vendor of biochemical reagents, assay kits, antibodies, and proteins.

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