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AM3102 Exclusive

Cayman Chemical Item Number 13452

KDS-5104 (CAS 213182-22-0)

AM3102 (CAS 213182-22-0)

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Description

Oleoyl ethanolamide (OEA) is an endogenous agonist for proliferator-activated receptor α (PPARα) that suppresses food intake, promotes lipolysis, and reduces weight gain in rodents. The biological effects of OEA are terminated by fatty-acid amide hydrolase and N-acylethanolamine-hydrolyzing acid amidase. AM3102 is an OEA analog that stimulates PPARα transcriptional activity with an EC50 value of 100 nM and prolongs feeding latency in rodents with an ED50 value of 2.4 mg/kg.1 It is resistant to enzymatic hydrolysis and is as potent as OEA in enhancing transcriptional activity of PPARα and reducing food intake in free-feeding rats.1,2 AM3102 demonstrates weak affinity for the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors with Ki values of 33 and 26 µM, respectively.3

1 Astarita, G., Di Giacomo, B., Gaetani, S., et al. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J Pharmacol Exp Ther 318(2) 563-570 (2006).

2 Wang, J., and Ueda, N. Role of the endocannabinoid system in metabolic control. Curr Opin Nephrol Hypertens 17 1-10 (2008).

3 Lin, S., Khanolkar, A.D., Fan, P., et al. Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. J Med Chem 41 5353-5361 (1998).

Synonyms
  • KDS-5104
Formal Name N-​[(1R)-​2-​hydroxy-​1-​methylethyl-​9Z-​octadecenamide
CAS Number 213182-22-0
Molecular Formula C21H41NO2
Formula Weight 339.6
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC[C@@H]​(C)​NC(CCCCCCC/C=C\CCCCCCCC)​=O

Background Reading

Wang, J., and Ueda, N. Role of the endocannabinoid system in metabolic control. Curr Opin Nephrol Hypertens 17 1-10 (2008).

Lin, S., Khanolkar, A.D., Fan, P., et al. Novel analogues of arachidonylethanolamide (anandamide): Affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability. J Med Chem 41 5353-5361 (1998).

Astarita, G., Di Giacomo, B., Gaetani, S., et al. Pharmacological characterization of hydrolysis-resistant analogs of oleoylethanolamide with potent anorexiant properties. J Pharmacol Exp Ther 318(2) 563-570 (2006).

AM3102 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $35.00 $0.00
10 mg $67.00 $0.00
50 mg $280.00 $0.00
100 mg $490.00 $0.00
Bulk Contact
Cart Total $0.00

This product is available in custom sizes and/or larger quantities.

Please contact our Sales Department for a quote or to purchase.

Pricing updated 2012-05-26. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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