SIRT7 Polyclonal Antibody

Cayman Chemical Item Number 13477

Silent Information Regulator 7; Sirtuin 7; Sir2

SIRT7 Polyclonal Antibody

See more	Western Blot (557) Antibodies (630) Chromatin Research (137) Epigenetics (175) Histone Modification (126)

Description

Antigen: human SIRT7 amino acids 35-51 and 361-377 · Host: rabbit · Application(s): WB · SIRT7 is a member of a famiy of proteins called sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast, and mammalian sirtuins are able to metabolize NAD⁺ and several act as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD⁺ metabolism and NAD⁺-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD⁺ and the N-e-acetyl-lysine groups of acetylated histone.

Synonyms

Silent Information Regulator 7
Sirtuin 7
Sir2

Formulation

100 µg of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide

Stability

1 year

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Specificity

Human SIRT7

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1 ea	$224.00		$0.00
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Pricing updated 2012-02-11. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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SIRT7 Polyclonal Antibody

SIRT7 Polyclonal Antibody

Description

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